New grant for rickets study

Yale University has received a five-year, $5 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to form a Center of Research Translation (CORT), one of four in the country, to provide models of translational research in academic medical centers. The Yale CORT will focus on X-linked hypophosphatemic rickets (XLH), the most common form of inherited rickets in the United States. XLH can lead to deformed bones, fractures and debilitating arthritis.

The Yale Center for XLH, directed by Thomas O. Carpenter, M.D., professor of pediatrics, and co-directed by Karl L. Insogna, M.D., professor of medicine (endocrinology), has as its goals the identification and validation of mediators of skeletal disease in XLH and the development of therapeutics based on this knowledge. The center will support an educational program, a pilot projects program and three scientific studies, as well as a research core.

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